STIC-Members: Martin Muik

An Overview

Curriculum vitae

Born:

22.07.1981 in Braunau/Inn

Family status:

unmarried

Children:

one daughter

Address:

Johann-Wilhelm-Klein Str. 72
A-4040 Linz
phone: +4369911059575
e-mail: martin.muik@gmx.at

Education:

1987-1991 Elementary School
1991-1995 Grammer School
1995-2000 Higher Technical School
2000-2001 Military Service
2001-2006 University of Linz, technical physics - biophysics Diploma thesis at University of Linz: "Regulatory mechanisms of Store-Operating-Channels (SOC) and Transient-Receptor-Potential-Channels (TRP)"
2006-2009PhD - Program: Molecular Bioanalytics - University of Linz
Doctoral thesis at University of Linz:
"Elucidation of the mechanism of TIM1 and Orai coupling by FRET microscopy

Memberships:

TFC-Wal05

List of publications:

Meetings:

Talks:

09/2006 GEN-AU summer school - Litschau, Austria
Muik M, Fritsch R, Derler I, Kahr H, Schindl R, Romanin C.
In vivo interaction of calmodulin (CaM) with TRPV6 channels evaluated by confocal FRET microscopy

09/2007 Doctoral Program Molecular Bioanalytics meeting - Saalbach, Austria
M. Muik, I.Frischauf, I. Derler, M. Fahrner, B. Polzinger, R.Schindl, J. Bergsmann, R. Fritsch, H. Kahr, J. Madl, K. Groschner, C. Romanin;
SOC - Stim Orai Coupling

09/2008 Doctoral Program Molecular Bioanalytics meeting - St. Wolfgang, Austria
Muik M, Frischauf I, Derler I, Fahrner M, Polzinger B, Schindl R, Bergsmann J, Fritsch R, Kahr H, Madl J, Groschner K, Romanin C.
SOC - Stim Orai Coupling

09/2008 Invited Talk - Graz, Austria
Muik M, Frischauf I, Derler I, Fahrner M, Polzinger B, Schindl R, Bergsmann J, Fritsch R, Kahr H, Madl J, Groschner K, Romanin C.
SOC - Stim Orai Coupling

02/2009 Regional Biophysics Conference - Linz, Austria
Muik M, Frischauf I, Derler I, Fahrner M, Polzinger B, Schindl R, Bergsmann J, Fritsch R, Kahr H, Madl J, Groschner K, Romanin C.
SOC - Stim Orai Coupling

Posters:

09/2006 GEN-AU summer school - Litschau, Austria
Martin Muik, Reinhard Fritsch, Isabella Derler, Heike Kahr, Rainer Schindl, Christoph Romanin.
In vivo interaction of calmodulin (CaM) with TRPV6 channels evaluated by confocal FRET microscopy

03/2007 IX Annual Linzer Winterworkshop - Linz, Austria
Muik M, Fritsch R, Derler I, Kahr H, Schindl R, Romanin C.
In vivo interaction of calmodulin (CaM) with TRPV6 channels evaluated by confocal FRET microscopy

02/2008 52nd biophysical Society meeting - Long Beach, California, USA
Muik M, Frischauf I, Derler I, Fahrner M, Polzinger B, Schindl R, Bergsmann J, Fritsch R, Kahr H, Madl J, Groschner K, Romanin C.
Ca2+ store depletion triggers a dynamic, physical coupling of STIM1 to ORAI1

03/2008 X Annual Linzer Winterworkshop - Linz, Austria
Muik M, Frischauf I, Derler I, Fahrner M, Polzinger B, Schindl R, Bergsmann J, Fritsch R, Kahr H, Madl J, Groschner K, Romanin C.
Ca2+ store depletion triggers a dynamic, physical coupling of STIM1 to ORAI1

09/2008 Doctoral Program Molecular Bioanalytics meeting - St. Wolfgang, Austria
Muik M, Romanin C.
Structure – function analysis and regulation of TRP channels

09/2008 European Calcium Society meeting - Leuven, Belgium
Muik M, Frischauf I, Derler I, Fahrner M, Eder P, Schindl R, Hesch C, Bergsmann J, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.
Coupling of the putative coiled – coil domain of ORAI proteins with STIM1 mediates ORAI channel activation

02/2009 Regional Biophysics Conference - Linz, Austria
Muik M, Fahrner M, Derler I, Schindl R, Frischauf I, Bergsmann J, Fritsch R, Madl J, Groschner K, Romanin C.
An ORAI activating minimal fragment of STIM1

02/2009 53rd biophysical Society meeting - Boston, Massachusetts, USA
Muik M, Fahrner M, Derler I, Schindl R, Frischauf I, Bergsmann J, Fritsch R, Madl J, Groschner K, Romanin C.
An ORAI activating minimal fragment of STIM1

03/2009 XI Annual Linzer Winterworkshop - Linz, Austria
Muik M, Fahrner M, Derler I, Schindl R, Frischauf I, Bergsmann J, Fritsch R, Madl J, Groschner K, Romanin C.
An ORAI activating minimal fragment of STIM1

06/2009 Gordon Research Conference on Calcium Signalling - Lucca, Italy
Muik M, Frischauf I, Derler I, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.
Molecular determinants of the coupling between STIM1 and Orai channels: Differentialactivation of Orai1,2,3 channels by a STIM1 coiled-coil mutant

Full papers:

  1. Derler I, Hofbauer M, Kahr H, Fritsch R, Muik M, Kepplinger K, Hack ME, Moritz S, Schindl R, Groschner K, Romanin C.
    Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation.
    J. Pysiol. 2006 Nov 15;577(Pt 1):31-44.
  2. Schindl R*, Frischauf I*, Kahr H, Fritsch R, Krenn M, Derndl A, Vales E, Muik M, Derler I, Groschner K, Romanin C.
    The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels;
    Cell Calcium.; 43(3):260-9;
  3. Muik M*, Frischauf I*, Derler I*, Fahrner M, Bergsmann J, Eder P, Schindl R, Hesch C, Polzinger B, Fritsch R, Kahr H, Madl J, Gruber H, Groschner K, Romanin C.
    Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation
    J Biol Chem. 2008 Mar 21;283(12):8014-22.
    Mentioned as Research Highlight in Nature: Come together; Vol 451; 503
  4. Schindl R*, Bergsmann J*, Frischauf I, Derler I, Fahrner M, Muik M, Fritsch R, Groschner K, Romanin C.
    2-aminoethoxydiphenyl borate alters selectivity of Orai3 channels by increasing their pore size
    J Biol Chem. 2008 Jul 18;283(29):20261-7. Epub 2008 May 21.
  5. Muik M*, Fahrner M*, Derler I*, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.
    A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
    J Biol Chem. 2009 Mar 27; 284(13):8421-6. Epub 2009 Feb 3
  6. Derler I*, Fahrner M*, Carugo O, Muik M, Bergsmann J, Schindl R, Frischauf I, Eshaghi S, Romanin C.
    Increased hydrophobicity at the N-terminus/membrane interface impairs gating of the SCID-related ORAI1 mutant.
    J Biol Chem. 2009 Jun 5;284(23):15903-15. Epub 2009 Apr 14
  7. Fahrner M, Muik M, Derler I, Schindl R, Fritsch R, Frischauf I, Romanin C.
    Invited Review: A mechanistic view of domains mediating STIM1-Orai coupling.
    Immunol Rev. 2009 Sep;231(1):99-112. Review.
  8. Frischauf I*, Muik M*, Derler I*, Bergsmann J, Fahrner M, Schindl R, Groschner K, Romanin C.
    Molecular determinants of the coupling between STIM1 and Orai channels: Differential activation of Orai1,2,3 channels by a STIM1 mutant.
    J Biol Chem. 2009 Aug 7;284(32):21696-706. Epub 2009 Jun 8.
  9. Gößler-Schöfberger R, Hesser G, Muik, M, Wechselberger C, Jilek A.
    An orphan dermaseptin from frog skin reversibly assembles to amyloid-like aggregates in a pH-dependent fashion
    FEBS J. 2009 Oct;276(20):5849-59. Epub 2009 Sep 17.
  10. Derler I*, Fahrner M*, Muik M*, Lackner B, Schindl R, Groschner K, Romanin C.
    A CRAC modulatory domain (CMD) within STIM1 mediates fast Ca2+-dependent inactivation of ORAI channels.
    J Biol Chem. 2009 Sep 11;284(37):24933-8. Epub 2009 Jul 21.
  11. Muik M*, Fahrner M*, Derler I*, Schindl R, Bergsmann J, Frischauf I, Groschner K, Romanin C.
    Invited article: addendum on A Cytosolic Homomerization and a Modulatory Domain within STIM1 C Terminus Determine Coupling to ORAI1 Channels.
    Submitted to Channels.
  12. Schindl R*, Frischauf I*, Bergsmann J*, Muik M, Derler I, Lackner B, Groschner K, Romanin C.
    Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel.
    Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19623-19628. Epub 2009 Nov 3.

*These authors contributed equally

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